Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency
نویسندگان
چکیده
منابع مشابه
Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.
Light has profound effects on mood, as exemplified by seasonal affective disorder (SAD) and the beneficial effects of bright light therapy. However, the underlying neural pathways through which light regulates mood are not well understood. Our previous work has developed the diurnal grass rat, Arvicanthis niloticus, as an animal model of SAD (Leach et al., 2013a,b). By utilizing a 12:12-h dim l...
متن کاملDepression-Like Responses Induced by Daytime Light Deficiency in the Diurnal Grass Rat (Arvicanthis niloticus)
Seasonal Affective Disorder (SAD) is one of the most common mood disorders with depressive symptoms recurring in winter when there is less sunlight. The fact that light is the most salient factor entraining circadian rhythms leads to the phase-shifting hypothesis, which suggests that the depressive episodes of SAD are caused by misalignments between the circadian rhythms and the habitual sleep ...
متن کاملOrexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus.
Seasonal affective disorder (SAD), a major depressive disorder recurring in the fall and winter, is caused by the reduction of light in the environment, and its depressive symptoms can be alleviated by bright light therapy. Both circadian and monoaminergic systems have been implicated in the etiology of SAD. However, the underlying neural pathways through which light regulates mood are not well...
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In humans, light enhances both alertness and performance during nighttime and daytime [1-4] and influences regional brain function [5]. These effects do not correspond to classical visual responses but involve a non-image forming (NIF) system, which elicits greater endocrine, physiological, neurophysiological, and behavioral responses to shorter light wavelengths than to wavelengths geared towa...
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Depression is an affective disorder characterized, in particular in its more severe form, i.e., major depressive disorder (MDD), by persistent symptoms of unpleasant (dysphoric) mood, inability to experience pleasure (anhedonia), and a generalized loss of interest in most or all normal activities [1]. Depression is often associated with physiological and cognitive symptoms. Physiological sympto...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2014
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2014.04.069